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Bergamot BPF contains a powerful and unique array of cholesterol-balancing and cardio-protective polyphenolic flavonoids.* Optimizing cardiovascular health is a leading concern for many adults, and maintaining balanced cholesterol levels are an important part of that process. Though cholesterol can be consumed through food, circulating cholesterol levels are primarily produced and controlled by the liver using the rate control enzyme, HMG-CoA reductase (HMGCR). Because of its pronounced role in cholesterol synthesis, inhibiting HMGCR has become a primary target of many traditional therapies. Numerous clinical trials have shown the specific BPF found in Bergamot BPF works at the level of the liver to help maintain and support healthy cholesterol levels and preserve coronary arteries by maintaining normal inflammatory balance.*

Formulated with the goal of building a healthy gastrointestinal (GI) flora, Candicid Forte includes biotin and sodium caprylate to support heathy yeast levels. It also includes potent botanicals, such as berberine HCl, Pau d’Arco, oregano, rosemary, cinnamon and ginger, to help sooth the GI tract, provide potent antioxidant support, and support healthy microbial balance.*

• Supports Joint Integrity and Movement* • Helps Protect Cartilage Cells • Maintains Healthy Inflammatory Balance* • Supports Synthesis of Proteoglycans for Healthy Connective Tissue* Cartilage is composed of collagen fibers that impart tensile strength, and proteoglycan molecules (especially chondroitin) that serve as a cushion for joint impact. Lifestyle factors and age can both contribute to a breakdown of healthy cartilage and lead to discomfort, which can lead to nutrient and fluid deprivation of the affected articular cartilage. While most other therapies simply block the pain of joint discomfort, the ingredients in Chondro-Flx address the root cause of joint discomfort and provide the precursors that enhance cartilage synthesis for healthy joints and connective tissue.* Chondro-Flx combines glucosamine sulfate, chondroitin sulfate, vitamin C and bromelain, all of which have a long history of use and a large body of research highlighting their role in supporting joint health. The formula also includes bromelain to enhance the absorption of chondroitin and vitamin C, an antioxidant that reduces free radicals and is a cofactor to enzymes critical for the synthesis of new collagen.*

• Supports Joint Integrity and Movement* • Helps Protect Cartilage Cells • Maintains Healthy Inflammatory Balance* • Supports Synthesis of Proteoglycans for Healthy Connective Tissue* Cartilage is composed of collagen fibers that impart tensile strength, and proteoglycan molecules (especially chondroitin) that serve as a cushion for joint impact. Lifestyle factors and age can both contribute to a breakdown of healthy cartilage and lead to discomfort, which can lead to nutrient and fluid deprivation of the affected articular cartilage. While most other therapies simply block the pain of joint discomfort, the ingredients in Chondro-Flx address the root cause of joint discomfort and provide the precursors that enhance cartilage synthesis for healthy joints and connective tissue.* Chondro-Flx combines glucosamine sulfate, chondroitin sulfate, vitamin C and bromelain, all of which have a long history of use and a large body of research highlighting their role in supporting joint health. The formula also includes bromelain to enhance the absorption of chondroitin and vitamin C, an antioxidant that reduces free radicals and is a cofactor to enzymes critical for the synthesis of new collagen.*

D-Hist Jr. is a great-tasting, chewable tablet that includes a targeted blend of flavonoids, antioxidants, proteolytic enzymes and botanicals designed to provide comprehensive support for children with seasonal challenges. D-Hist Jr. includes quercetin, a powerful flavonoid. It supplies bromelain to enhance the absorption of quercetin and to support mucosal tissue health and stinging nettles leaf to help balance immune response. N-acetyl cysteine helps promote normal viscosity of mucus. This unique nutritional combination safely promotes healthy nasal and sinus passages.*

The gastrointestinal tract is a finely balanced environment where roughly 500 different strains of bacteria compete for space and nutrients. The natural microflora balance can be disrupted by medications or poor dietary intake. One of the key benefits of probiotics is their ability to increase populations of healthy bacteria in the face of microflora imbalance. In addition, extensive research has identified other broad health benefits, including supporting healthy bowel function, increasing the production of important short-chain fatty acids, which provide energy to the cells of the intestinal lining, supporting immune function, aiding in the digestion of difficult-to-break-down compounds like lactose and casein, and supporting detoxification of harmful compounds. Flora Bites is a delicious, chewable probiotic formula for children, designed to promote healthy gut microflora, protect intestinal integrity and support immune function. Each creamy, natural orange-flavored cube contains a 5 billion CFU blend of Lactobacillus acidophilus and Bifidobacterium lactis, as well as 20 mg of vitamin C for comprehensive digestive and immune system support.* The strains in Flora Bites have been carefully selected for their survivability and adherence to the intestinal tract. The chewable cube form is an easy, fun way for children to achieve optimal probiotic support and a tasty alternative to a capsule or powdered probiotic.

The gastrointestinal (GI) tract is a finely balanced environment where roughly 500 different strains of bacteria compete for space and nutrients. The natural microflora balance can be disrupted by medications or poor dietary intake. One of the key benefits of probiotics is their ability to increase populations of healthy bacteria in the face of microflora imbalance. In addition, extensive research has identified other broad health benefits, including supporting healthy bowel function, increasing the production of important short-chain fatty acids that provide energy to the cells of the intestinal lining, supporting immune function, aiding in the digestion of difficult-to-break-down compounds like lactose and casein, and supporting detoxification of harmful compounds. Because probiotics are living organisms, there are various challenges associated with their manufacturing and distribution. For a probiotic to be effective, it must be shelf-stable through the expiration date and precisely delivered to the intestinal tract, where it can have maximum benefit. The microorganisms in FloraSupport are protected, sealed, and freeze dried away from moisture, heat, light and oxygen. This allows the bacteria to remain dormant until they are exposed to moisture in the GI tract. FloraSupport is a probiotic formula for children, designed to deliver live bacteria that promote healthy gut microflora, protect intestinal integrity and support immune function. The formula contains three strains of Lactobacilli and three strains of Bifidobacteria, as well as Streptococcus thermophilus and Saccharomyces boulardii, an extensively researched microorganism shown to help restore microflora balance by enhancing commensal organism function.* The eight strains in FloraSupport have been strategically selected based on research supporting their survivability and adherence to the intestinal tract. FloraSupport comes in a powder form for easy administration to children.

IgG Protect is a highly concentrated (40%) immunoglobulin G (IgG) formula that provides essential nutrition for immune health. IgG Protect’s pure and high-concentration formula provides support for immune modulation and gut-immune barrier.* Consistency in potency and purity of colostrum extracts is a primary concern for clinicians; advanced filtration and purification techniques make IgG Protect a superior clinical tool. IgG Protect provides 1,000 mg of IgG and 2 g of protein per serving.

IgG Protect is a highly concentrated (40%) immunoglobulin G (IgG) formula that provides essential nutrition for immune health. IgG Protect’s pure and high-concentration formula provides support for immune modulation and gut-immune barrier.* Consistency in potency and purity of colostrum extracts is a primary concern for clinicians; advanced filtration and purification techniques make IgG Protect a superior clinical tool. IgG Protect provides 1,000 mg of IgG and 2 g of protein per serving.

Imu-Max is a kosher children’s formula that supports immune function and provides support for immune challenges. Imu-Max contains echinacea, one of the best-known botanicals used to support the immune system, and propolis, a product of bee resin, which helps maintain normal inflammatory balance.* Imu-Max combines echinacea and propolis extracts in a pleasant-tasting liquid formula for immune system support.*

Methyl B Complex is formulated with eight essential B vitamins, choline, inositol, and folate to support energy production, and immune, cardiovascular and neurological health.*

Natural D-Hist is a targeted blend of flavonoids, antioxidants, proteolytic enzymes and botanicals designed to provide comprehensive support for seasonal challenges caused by common environmental allergens. Natural D- Hist includes quercetin, a powerful flavonoid, to support healthy histamine levels. Bromelain enhances the absorption of quercetin and supports mucosal tissue health. Stinging nettles leaf balance hyper-immune response and N-acetyl cysteine clear the airways by promoting normal viscosity of mucus. This powerful combination actively promotes healthy nasal and sinus passages for individuals with elevated histamine and respiratory irritation. Also available in convenient blister packs.

Quercetin* Quercetin is a biologically active flavonoid antioxidant that is widely distributed in plants including oak trees, onions and tea. Quercetin has strong antioxidant activity and has been shown to support immune health by mediating the release of inflammatory compounds including leukotrienes and prostaglandins. Quercetin is known for its ability to stabilize mast cells, diminishing the release of histamine, the compound known to cause hypersensitivity reactions during seasonal changes.

Stinging Nettles Leaf* Urtica dioica, commonly known as stinging nettles, is a plant that has been shown to balance immune response, specifically in the airways and nasal passages. Studies have shown that the extract of stinging nettles leaf balances a variety of inflammatory activities that affect respiratory health. Stinging nettles leaf controls mast-cell degranulation, prostaglandin formation, and histamine action all contributing to a balanced inflammatory response.

Bromelain* Bromelain is a plant enzyme naturally found on the stem and fruit of the pineapple plant. Bromelain is a proteolytic enzyme that aids in in the breakdown of large protein complexes, including antigenic compounds, and has been shown to enhance the absorption of quercetin. Bromelain has been shown to reduce circulating allergenic protein complexes associated with hyper-immune sensitivity and seasonal discomfort.

N-Acetyl Cysteine* N-acetyl cysteine (NAC) is an amino acid precursor to one of the most important antioxidants in the body, glutathione. Both glutathione and NAC help reduce the viscosity of the mucus allowing for clearing of the airways and improved respiratory health.

Vitamin C* Vitamin C cannot be synthesized by humans and is therefore an essential nutrient that must be consumed in the diet. Among its numerous health-promoting properties, vitamin C is an essential vitamin that supports the immune system and is also a potent antioxidant. When the body is under a significant amount of stress, both emotional and environmental, vitamin C is excreted rapidly. Vitamin C has many immune boosting properties but is distinctively beneficial for individuals with seasonal discomfort because of its ability to deactivate histamine.

Natural D-Hist is a targeted blend of flavonoids, antioxidants, proteolytic enzymes and botanicals designed to provide comprehensive support for seasonal challenges caused by common environmental allergens. Natural D- Hist includes quercetin, a powerful flavonoid, to support healthy histamine levels. Bromelain enhances the absorption of quercetin and supports mucosal tissue health. Stinging nettles leaf balance hyper-immune response and N-acetyl cysteine clear the airways by promoting normal viscosity of mucus. This powerful combination actively promotes healthy nasal and sinus passages for individuals with elevated histamine and respiratory irritation. Also available in convenient blister packs.

Quercetin* Quercetin is a biologically active flavonoid antioxidant that is widely distributed in plants including oak trees, onions and tea. Quercetin has strong antioxidant activity and has been shown to support immune health by mediating the release of inflammatory compounds including leukotrienes and prostaglandins. Quercetin is known for its ability to stabilize mast cells, diminishing the release of histamine, the compound known to cause hypersensitivity reactions during seasonal changes.

Stinging Nettles Leaf* Urtica dioica, commonly known as stinging nettles, is a plant that has been shown to balance immune response, specifically in the airways and nasal passages. Studies have shown that the extract of stinging nettles leaf balances a variety of inflammatory activities that affect respiratory health. Stinging nettles leaf controls mast-cell degranulation, prostaglandin formation, and histamine action all contributing to a balanced inflammatory response.

Bromelain* Bromelain is a plant enzyme naturally found on the stem and fruit of the pineapple plant. Bromelain is a proteolytic enzyme that aids in in the breakdown of large protein complexes, including antigenic compounds, and has been shown to enhance the absorption of quercetin. Bromelain has been shown to reduce circulating allergenic protein complexes associated with hyper-immune sensitivity and seasonal discomfort.

N-Acetyl Cysteine* N-acetyl cysteine (NAC) is an amino acid precursor to one of the most important antioxidants in the body, glutathione. Both glutathione and NAC help reduce the viscosity of the mucus allowing for clearing of the airways and improved respiratory health.

Vitamin C* Vitamin C cannot be synthesized by humans and is therefore an essential nutrient that must be consumed in the diet. Among its numerous health-promoting properties, vitamin C is an essential vitamin that supports the immune system and is also a potent antioxidant. When the body is under a significant amount of stress, both emotional and environmental, vitamin C is excreted rapidly. Vitamin C has many immune boosting properties but is distinctively beneficial for individuals with seasonal discomfort because of its ability to deactivate histamine.

Natural D-Hist is a targeted blend of flavonoids, antioxidants, proteolytic enzymes and botanicals designed to provide comprehensive support for seasonal challenges caused by common environmental allergens. Natural D- Hist includes quercetin, a powerful flavonoid, to support healthy histamine levels. Bromelain enhances the absorption of quercetin and supports mucosal tissue health. Stinging nettles leaf balance hyper-immune response and N-acetyl cysteine clear the airways by promoting normal viscosity of mucus. This powerful combination actively promotes healthy nasal and sinus passages for individuals with elevated histamine and respiratory irritation. Also available in convenient blister packs.

Quercetin* Quercetin is a biologically active flavonoid antioxidant that is widely distributed in plants including oak trees, onions and tea. Quercetin has strong antioxidant activity and has been shown to support immune health by mediating the release of inflammatory compounds including leukotrienes and prostaglandins. Quercetin is known for its ability to stabilize mast cells, diminishing the release of histamine, the compound known to cause hypersensitivity reactions during seasonal changes.

Stinging Nettles Leaf* Urtica dioica, commonly known as stinging nettles, is a plant that has been shown to balance immune response, specifically in the airways and nasal passages. Studies have shown that the extract of stinging nettles leaf balances a variety of inflammatory activities that affect respiratory health. Stinging nettles leaf controls mast-cell degranulation, prostaglandin formation, and histamine action all contributing to a balanced inflammatory response.

Bromelain* Bromelain is a plant enzyme naturally found on the stem and fruit of the pineapple plant. Bromelain is a proteolytic enzyme that aids in in the breakdown of large protein complexes, including antigenic compounds, and has been shown to enhance the absorption of quercetin. Bromelain has been shown to reduce circulating allergenic protein complexes associated with hyper-immune sensitivity and seasonal discomfort.

N-Acetyl Cysteine* N-acetyl cysteine (NAC) is an amino acid precursor to one of the most important antioxidants in the body, glutathione. Both glutathione and NAC help reduce the viscosity of the mucus allowing for clearing of the airways and improved respiratory health.

Vitamin C* Vitamin C cannot be synthesized by humans and is therefore an essential nutrient that must be consumed in the diet. Among its numerous health-promoting properties, vitamin C is an essential vitamin that supports the immune system and is also a potent antioxidant. When the body is under a significant amount of stress, both emotional and environmental, vitamin C is excreted rapidly. Vitamin C has many immune boosting properties but is distinctively beneficial for individuals with seasonal discomfort because of its ability to deactivate histamine.

The GI tract is a finely balanced environment where roughly 500 different strains of bacteria compete for space and nutrients. When there is a healthy balance (eubiosis), few symptoms exist. The natural microflora balance can be upset by medications, excessive alcohol consumption, or poor dietary intake. Because probiotics are live organisms, there are many challenges associated with manufacturing and distributing probiotic supplements. For a probiotic to be effective, it must be shelf-stable through the expiration date and precisely delivered to the intestinal tract, where it can have maximum benefit. BioShield® technology is an innovative manufacturing process developed to ensure consistent and reliable results. The microorganisms in Ortho Biotic are protected, sealed and freeze dried away from moisture, heat, light and oxygen. This allows the bacteria to remain dormant until they are exposed to moisture in the GI tract. By utilizing advanced encapsulation technology, the probiotic organisms are preserved and released on-target for maximum benefit. Ortho Biotic is a unique probiotic formula designed to deliver active organisms shown to promote healthy gut microflora, protect intestinal integrity and support immune function. Included in this formula is Saccharomyces boulardii, an extensively researched microorganism shown to help restore microflora balance by enhancing commensal organism function. Each Ortho Biotic capsule provides seven proven probiotic strains chosen for their ability to withstand the harsh gastrointestinal (GI) environment and adhere to the intestinal tract to deliver superior results.*

• Accelerates the Proliferation of Healthy Intestinal Microflora* • Promotes a Rapid Immune Response* • Maintains Healthy Inflammatory Balance* Going beyond the threshold of traditional probiotic support, high-dose probiotics influence gut health and immunity in ways lower-dose probiotics cannot. Delivering 225 billion active probiotic cultures per packet, Probiotic 225 creates a rapid response to reset the immune system and maintain normal inflammatory balance.* Each convenient, single serving packet provides six proven strains chosen for their ability to survive the harsh GI environment and deliver superior results.

The standardized nutrients and botanicals in Sinatrol help support microflora balance, promote normal mucus viscosity for healthy sinus function, and promote a balanced inflammatory response.* Also available in convenient blister packs. Optimal sinus health requires proper circulation through the sinus cavities that is free of mucus build-up. The sinuses are composed of hollow cavities that are lined with soft tissue, called mucosa. Under healthy conditions, the sinuses are empty and contain a thin layer of mucus. A healthy process that occurs in the sinus cavities, termed mucociliary clearance, allows the ciliated epithelium (hair-like structures located on tissues), in coordination with mucus production, to continually remove waste from the sinuses by facilitating drainage and particle removal. Typical particles that collect in the sinus cavities include dust, pollen, dirt, allergens and fungi. Sinatrol contains a synergistic blend of ingredients that support sinus health by increasing mucociliary clearance, decreasing the build-up of mucus and supporting immune response during seasonal respiratory challenges.*

The standardized nutrients and botanicals in Sinatrol help support microflora balance, promote normal mucus viscosity for healthy sinus function, and promote a balanced inflammatory response.* Also available in convenient blister packs. Optimal sinus health requires proper circulation through the sinus cavities that is free of mucus build-up. The sinuses are composed of hollow cavities that are lined with soft tissue, called mucosa. Under healthy conditions, the sinuses are empty and contain a thin layer of mucus. A healthy process that occurs in the sinus cavities, termed mucociliary clearance, allows the ciliated epithelium (hair-like structures located on tissues), in coordination with mucus production, to continually remove waste from the sinuses by facilitating drainage and particle removal. Typical particles that collect in the sinus cavities include dust, pollen, dirt, allergens and fungi. Sinatrol contains a synergistic blend of ingredients that support sinus health by increasing mucociliary clearance, decreasing the build-up of mucus and supporting immune response during seasonal respiratory challenges.*

IMMUNE HEALTH Viracid includes a powerful combination of key nutrients and botanical extracts that provide support for immune challenges. Viracid boosts immune defenses by providing nutrients such as L-lysine vitamins A and C, pantothenic acid, B12, and zinc. Viracid includes the synergistic blend of botanical extracts black elderberry, astragalus, echinacea, and andrographis, all of which have been used traditionally for their clinically effective immune- modulating properties. OVERVIEW Our body’s immune system is a complex and dynamic defense system that comes to our rescue at the first sign of exposure to an outside invader. The dynamic nature of the immune system means that all factors that affect health need to be addressed in order for it to function at peak performance. The immune system is very sensitive to nutrient deficiencies. While vitamin deficiencies can compromise the immune system, consuming immune enhancing nutrients and botanicals can support and strengthen your body’s immune response. Viracid’s synergistic formula significantly boosts immune cell function including antibody response, natural killer (NK) cell activity, thymus hormone secretions, and T-cell activation. Viracid also helps soothe throat irritations and nasal secretions, and maintains normal inflammatory balance by increasing antioxidant levels throughout the body. IMMUNE NUTRITION BASE* Viracid contains the synergistic nutrient blend of zinc, vitamin C, vitamin A, L-lysine and pantothenic acid which each play a major role in maintaining a healthy, functioning immune system. ZINC* Zinc is a mineral that works synergistically with vitamin A in activating thymic factor, a thymus hormone with vital immune supporting properties. Maintaining optimal zinc levels also helps maintain helper T-cell lymphocyte function, NK cell activity, macrophage function, and antibody production. VITAMIN C* Vitamin C is well known for its ability to support immune response. Vitamin C concentrations decline rapidly in the body during periods of stress. Dietary intake is therefore crucial during immune challenges. Vitamin C has been found to be helpful in supporting specific components of the immune system including NK cell activity and lymphocyte function. Vitamin C also provides antioxidant support by protecting cells against reactive oxygen species that are generated during normal inflammatory response. VITAMIN A* Vitamin A helps support mucous membranes. When vitamin A is lacking, mucus-producing cells are replaced by keratin-producing cells, and the membranes become tough and more vulnerable to organisms. Vitamin A is a critical immune supporting nutrient. Vitamin A also supports the immune system by stimulating white blood cell function and increasing antibody response. L-LYSINE* L-lysine is an essential amino acid that cannot be synthesized in the body on its own. Lysine must be derived from protein sources in the diet in order for the body to function properly. Many biological functions require lysine including boosting immune defense. A study conducted in China examined the immunological effects of lysine. Of eighty-eight families included in the study, half received wheat flour fortified with 3 g of lysine per kilogram of flour, the other half received wheat flour without fortification. Those given the fortified flour showed improved immune function, versus the placebo group, specifically showing an increase of CD3 T-cells, IgG, IgA, and IgM. PANTOTHENIC ACID (VITAMIN B5)* Pantothenic acid (vitamin B5) is a water-soluble B complex vitamin. D-calcium pantothenate is a heat stable form of B5. About 85% of pantothenic acid in food occurs as a component of coenzyme A (CoA). As a component of CoA, pantothenic acid is essential for the production of energy from carbohydrates, fats and protein. Maintaining optimal pantothenic acid levels is crucial for supporting immune system energy, thymic function and healthy white blood cell levels. BLACK ELDERBERRY EXTRACT* Black elderberry (Sambucas nigra) has a long history of traditional use among herbalists and is native to Europe, Northern Africa, and Western and Central Asia. Elderberry preparations range from expressed juice to syrup, tea decoction, powdered extract, and powdered extract in the form of lozenges or capsules. The bioactive components of elderberry include the flavonoid anthocyanin. Viracid is standardized to include black elderberry extract with 13% anthocyanins. Black elderberry preparations have also been shown to enhance immune cell killing potential by supporting healthy cytokine production, including IL-8 and IL-10, the cellular pathways used to eliminate foreign invaders. ASTRAGALUS MEMBRANACEUS ROOT EXTRACT* Astragalus membranaceus is native to northern China and has been traditionally used to strengthen the immune system. The root of A. membranaceus is one of the two commonly used species in traditional Chinese medicine. Research has demonstrated the immune-regulating effects of astragalus which include boosting T-dependent antigens, and lymphokine-activated killer (LAK) cells and macrophage activity. Additional studies have demonstrated that A. membranaceus root extract supports immune response by boosting T3, T4and T4/T8 cell ratios. ECHINACEA PURPUREA EXTRACT* Echinacea purpurea is a perennial herb that has been used for centuries in Native American medicine. Current research has supported echinacea’s clinical applications as this botanical has been the subject of more than 300 scientific studies. Echinacea activates multiple aspects of immune function including enhancing leukocyte and granulocyte counts, activating neutrophils, monocytes, and eosinophils and solubilizing immune complexes. Echinacea has been shown to compete with pathogens by blocking viral receptors on cell surfaces. Echinacea also diminishes hyaluronidase, a compound which increases connective tissue permeability and allows pathogenic organisms to become more invasive.

IMMUNE HEALTH Viracid includes a powerful combination of key nutrients and botanical extracts that provide support for immune challenges. Viracid boosts immune defenses by providing nutrients such as L-lysine vitamins A and C, pantothenic acid, B12, and zinc. Viracid includes the synergistic blend of botanical extracts black elderberry, astragalus, echinacea, and andrographis, all of which have been used traditionally for their clinically effective immune- modulating properties. OVERVIEW Our body’s immune system is a complex and dynamic defense system that comes to our rescue at the first sign of exposure to an outside invader. The dynamic nature of the immune system means that all factors that affect health need to be addressed in order for it to function at peak performance. The immune system is very sensitive to nutrient deficiencies. While vitamin deficiencies can compromise the immune system, consuming immune enhancing nutrients and botanicals can support and strengthen your body’s immune response. Viracid’s synergistic formula significantly boosts immune cell function including antibody response, natural killer (NK) cell activity, thymus hormone secretions, and T-cell activation. Viracid also helps soothe throat irritations and nasal secretions, and maintains normal inflammatory balance by increasing antioxidant levels throughout the body. IMMUNE NUTRITION BASE* Viracid contains the synergistic nutrient blend of zinc, vitamin C, vitamin A, L-lysine and pantothenic acid which each play a major role in maintaining a healthy, functioning immune system. ZINC* Zinc is a mineral that works synergistically with vitamin A in activating thymic factor, a thymus hormone with vital immune supporting properties. Maintaining optimal zinc levels also helps maintain helper T-cell lymphocyte function, NK cell activity, macrophage function, and antibody production. VITAMIN C* Vitamin C is well known for its ability to support immune response. Vitamin C concentrations decline rapidly in the body during periods of stress. Dietary intake is therefore crucial during immune challenges. Vitamin C has been found to be helpful in supporting specific components of the immune system including NK cell activity and lymphocyte function. Vitamin C also provides antioxidant support by protecting cells against reactive oxygen species that are generated during normal inflammatory response. VITAMIN A* Vitamin A helps support mucous membranes. When vitamin A is lacking, mucus-producing cells are replaced by keratin-producing cells, and the membranes become tough and more vulnerable to organisms. Vitamin A is a critical immune supporting nutrient. Vitamin A also supports the immune system by stimulating white blood cell function and increasing antibody response. L-LYSINE* L-lysine is an essential amino acid that cannot be synthesized in the body on its own. Lysine must be derived from protein sources in the diet in order for the body to function properly. Many biological functions require lysine including boosting immune defense. A study conducted in China examined the immunological effects of lysine. Of eighty-eight families included in the study, half received wheat flour fortified with 3 g of lysine per kilogram of flour, the other half received wheat flour without fortification. Those given the fortified flour showed improved immune function, versus the placebo group, specifically showing an increase of CD3 T-cells, IgG, IgA, and IgM. PANTOTHENIC ACID (VITAMIN B5)* Pantothenic acid (vitamin B5) is a water-soluble B complex vitamin. D-calcium pantothenate is a heat stable form of B5. About 85% of pantothenic acid in food occurs as a component of coenzyme A (CoA). As a component of CoA, pantothenic acid is essential for the production of energy from carbohydrates, fats and protein. Maintaining optimal pantothenic acid levels is crucial for supporting immune system energy, thymic function and healthy white blood cell levels. BLACK ELDERBERRY EXTRACT* Black elderberry (Sambucas nigra) has a long history of traditional use among herbalists and is native to Europe, Northern Africa, and Western and Central Asia. Elderberry preparations range from expressed juice to syrup, tea decoction, powdered extract, and powdered extract in the form of lozenges or capsules. The bioactive components of elderberry include the flavonoid anthocyanin. Viracid is standardized to include black elderberry extract with 13% anthocyanins. Black elderberry preparations have also been shown to enhance immune cell killing potential by supporting healthy cytokine production, including IL-8 and IL-10, the cellular pathways used to eliminate foreign invaders. ASTRAGALUS MEMBRANACEUS ROOT EXTRACT* Astragalus membranaceus is native to northern China and has been traditionally used to strengthen the immune system. The root of A. membranaceus is one of the two commonly used species in traditional Chinese medicine. Research has demonstrated the immune-regulating effects of astragalus which include boosting T-dependent antigens, and lymphokine-activated killer (LAK) cells and macrophage activity. Additional studies have demonstrated that A. membranaceus root extract supports immune response by boosting T3, T4and T4/T8 cell ratios. ECHINACEA PURPUREA EXTRACT* Echinacea purpurea is a perennial herb that has been used for centuries in Native American medicine. Current research has supported echinacea’s clinical applications as this botanical has been the subject of more than 300 scientific studies. Echinacea activates multiple aspects of immune function including enhancing leukocyte and granulocyte counts, activating neutrophils, monocytes, and eosinophils and solubilizing immune complexes. Echinacea has been shown to compete with pathogens by blocking viral receptors on cell surfaces. Echinacea also diminishes hyaluronidase, a compound which increases connective tissue permeability and allows pathogenic organisms to become more invasive.

Vitamin D is a steroid vitamin, a group of fat soluble prohormones that are best known for the role they play in supporting bone health and aiding in the absorption of calcium and phosphate from the GI tract. However, a growing body of research highlights its important role in supporting other body systems, including cardiovascular and blood sugar balance.* Vitamin D3 50,000 IU is ideal for those who have difficulty achieving and maintaining peak vitamin D levels. For those who require an immediate boost in their vitamin D status, the vitamin D3 50,000 IU formulation is a convenient, effective way to get the substantial support they need.

New research is focusing on the synergistic relationship between vitamin K2 and vitamin D3, for bone and cardiovascular health. A group of naturally occurring and structurally similar, fat-soluble vitamins, vitamin K is essential for the proper utilization of calcium. Through its activation of the protein osteocalcin, vitamin K helps to bind newly absorbed calcium to the mineral matrix in bone. In addition, vitamin K has been found to help maintain bone mineral density by decreasing the activity of osteoclasts, a cell that breaks down the bone matrix. Vitamin K also provides critical cardiovascular protection by helping to activate matrix Gla protein (MGP), an inhibitor of circulatory calcification. Thus, vitamin K and vitamin D not only share similar qualities, but they also act synergistically within the body. The addition of MenaQ7® PRO to this formula is backed by extensive research. Dr. Leon Schurgers, world-renowned expert in vitamin K2 as MK-7 research for cardiovascular and bone health, and his team of research scientists have conducted over 15 clinical trials on MenaQ7® PRO through the University of Maastricht. Vitamin K2 with D3 includes 45 mcg of MenaQ7® PRO, the most widely studied form of vitamin K2 as MK-7, and 5,000 IU of vitamin D3 per capsule for optimal absorption and use by the body.

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